HIPPOCAMPAL NEURONS ISOLATED FROM RATS SUBJECTED TO THE VALPROIC ACID MODEL MIMIC IN VIVO SYNAPTIC PATTERN: EVIDENCE OF NEURONAL PRIMING DURING EARLY DEVELOPMENT IN AUTISM SPECTRUM DISORDERS

Abstract Background Autism spectrum disorders (ASD) are synaptopathies characterized by area-specific synaptic alterations and neuroinflammation.Structural and adhesive features of hippocampal synapses have been described in the valproic acid (VPA) model.However, neuronal and microglial contribution to hippocampal synaptic pattern and its time-cour

Mycotoxins in food are hazardous for animal and human health, resulting in food waste and exacerbating the critical global food security situation.In addition, they affect commerce, particularly the incomes of rural farmers.The grave consequences of these Age of the Primes contaminants require a comprehensive strategy for their elimination to prese

Although the sound absorption coefficients of conventional Circuit Board and nanofiber nonwoven fabrics (NF-NWFs) have been the subject of many previous studies, few studies have considered the estimation of transmission loss.Reported herein is an experimental and theoretical study into estimating the transmission loss of NF-NWFs using four estimat

Pharmacotherapy is the cornerstone treatment for patients with heart failure (HF) Circuit Board that uses drugs targeting the renin-angiotensin-aldosterone system (RAAS), including angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan.This